Spiramycin Resistance inStaphylococcus aureus

Vancomycin Resistance in Staphylococcus aureus Strains

An electron-microscopic study on morphological changes of Staphylococcus aureus treated with spiramycin.

Treatment of gonorrhoea with spiramycin.

Spiramycin is a relatively new antibiotic prepared from Streptomyces ambofaciens which was first isolated from a soil sample by French workers. It was reported on by Pinnert-Sindico, Ninet, PreudHomme and Cosar at the Washington Symposium on Antibiotics in 1954. It is available as a sulphate in yellowish capsules each of 0-5 g. protected by a thin coat of varnish. So far there have been few rep...

Vancomycin Resistance in Staphylococcus aureus


The evolution of Staphylococcus aureus during the modern antibiotic era has been delineated by distinct strain emergence events, many of which include acquisition of antibiotic resistance. The relative high burden of methicillin-resistant S. aureus (MRSA) in healthcare and community settings is a major concern worldwide. Vancomycin, a glycopeptide antibiotic that inhibits cell wall biosynthesis...

Vancomycin resistance in Staphylococcus aureus.

Vancomycin resistance in enterococci, predominantly Enterococcus faecium, developed in the latter half of the 1980s, and the long anticipated development of vancomycin resistance in Staphylococcus aureus has now occurred. A number of vancomycin-intermediate strains have been described, and these strains have abnormal, thickened cell walls in the presence of vancomycin. Two mechanisms of resista...